Awesome 2 min video about canine bone marrow transplantation by the University of North Carolina

Thursday, May 6, 2010

May 6, 2010 - Angel's Leukopheresis Procedure at NC State!

Hi everyone, 


Dr. Suter called last night to let us know that Angel is still 100% cancer free! They moved forward and performed the Leukopheresis Procedure today. This is procedure will harvest Angel's stem cells for implantation tomorrow; it's sort of like dialysis. Angel was placed under light sedation; Dr. Suter had to speak quietly so he didn't wake her.

The procedure is painless in humans, but they often complain of being cold. They assume that it's the same for dogs, so they put a blanket over them to keep them warm.

These pictures were received a few hours ago while Angel was receiving the Leukopheresis Procedure at NC State!
The machine was running for 4-5 hours and then Dr. Suter called with wonderful news! Angel produced 1.7 million more cells than needed for the transplant! 


Humans sometimes save these cells, but Dr. Suter gives them all back to the dogs :) 
The more cells there are to pump in, the higher Angel's odds are of living cancer free for the rest of her long and happy life!

Tomorrow morning at 7am EST Angel will be prepped for full body irradiation. She will receive 2 doses of radiation in 1 hour intervals and Angel will be heavily sedated for the duration of the procedures.

They will take a 3 hour break between each hour on. After the radiation is complete Angel will receive her life-saving Canine Bone Marrow Transplant! This procedure has "taken" every time and they expect Angel to sail through with ease :) 


The irradiation will wipe out Angel's immune system, so a clean environment is critical to her recovery. She will wake up in ICU in a completely sterile room, safe from any outside germs or bacteria.


Thank you for following Angel’s progress!  I’ll keep you all updated as information comes in.  


Please visit our website for more information, http://www.save-an-angel.org/events.html and to donate to Angel's life-saving treatment!  Please help us spread the word :)  
     

Most Sincerely,
Kristie Sullens — Angel’s Mama
xoxoxoxoxoxoxox


Saturday, May 1, 2010

Destination Cure! Angel heads to North Carolina Sunday 5/2/10!


Tomorrow morning Angel will make her way to the cure! (5/2/10) We will load the car tonight and head out 1st thing in the morning.  Romeo, Angel, Johnny and I (Kristie) will drive 12 hours from New Orleans to North Carolina.  


We will get some rest and head to North Carolina State University on Monday.  We arrived a day early so that Angel has the opportunity to meet her new friends and get used to her new surroundings.  Monday evening we will buy Angel a steak dinner- or something like it - and then we'll shower her with love and pray for her speedy recovery.  


Tuesday, 5/4/10, we will check Angel into NCSU, This is when we will say goodbye to Angel and head back to Louisiana.  NCSU will be Angel's home for the next 2.5-3 weeks.  


Angel's Schedule:

  • May 1st: Neupogen injections
  • May 4th: Angel checks in at North Carolina State University
  • May 6th: Angel’s Leukaphresis Procedure
  • May 7th: Angel’s total body irradiation & transplant

We are grateful for every donation that has been made to save Angel's life! Every person that's donated has contributed to Angel's miracle, and we are forever grateful to all of you :) 


We will continue to fundraise while Angel is in the hospital.  The procedure is just the beginning, her need is still great.  Once Angel is checked in donations can be made directly to the school.  We still have roughly $6,000 to raise. 


We hope that watching Angel's progress  while she undergoes this life-saving procedure will inspire you to give and as always to help spread the word :) 


Please visit our blog, facebook and website http://www.save-an-angel.org/main.html often for updates!  We will fill you in every step of the way!




Kristie Sullens -- Angel's Mama   

Tuesday, April 27, 2010

5 Days Until Angel's Bone Marrow Transplant

I've watched Angel go through treatment for 7 months now and she's only appeared to be in pain a handful of times.  1 week ago Dr. Garon administered a full human dose of Cytoxin (chemo drug) to Angel in preparation for her bone marrow transplant.  Seeing Angel in such a weakened state makes me want to take her to the transplant clinic and drop her off tonight!  I couldn't imagine seeing her so sick and not being able to do anything about it.

I'm so grateful to all of you for helping us save Angel's life by donating so that she can receive the cure :)  What started out as a mission to save our dog's life has turned into a full blown movement to change the way we treat cancer in companion animals.

95% of transplants performed in humans were tested on dogs first.  95%!  Imagine all of the people you know that have received life-saving transplants.  If you don't know someone directly then you won't have to go far to find someone who does.  The point: most of these people are still alive to tell about it.   Once we found a way to cure lymphoma in humans the death rates dropped and the success rates skyrocketed!

Does it surprise you that cancer is the leading killer in dogs?  50% of dogs over the age of 10 will die from some form of cancer.  50%! That's a big number.  We have found ways to cure every dog ailment you can think of; heart disease, diabetes, paralysis you name it.  Why should cancer be any different?  We must keep pushing forward to help bridge the gap between dogs and humans.  They helped us before and they can do it again!  Why should the cure stop with humans when there is so much to be learned from what happens when we cure dogs?  Chemotherapy is a treatment but a bone marrow transplant is a cure!   What if there was an even better way to cure lymphoma and it's just waiting to be discovered?   Dogs were there to help us find a cure when we needed them the most.  Now it's our turn to give back and help them receive the cures they helped create!  

Angel is starting to perk up now and she even looks like she's going to eat :)  We will continue to monitor her temperature and pumping her full of meds and fluids.  Friday Angel goes back to the vet where they do a blood panel that will be sent to North Carolina.  Once North Carolina approves her blood work, Angel will be given her 1st of 6 Neupogen shots,  click to see Neupogen rx info .  The cost for this drug is $3,000 for 6 vials.  She will receive 2 shots per day until they are gone.  The shots will be administered from home.  We will transport the Neupogen shots to North Carolina in a cooler.

 We are close to our goal, but we still have a ways to go.  Anything that we don't have to borrow is a god send for our family.  We are offering beautiful bracelets, doggy decor & even dog clothes in return for your donations.
We also encourage you to spread the word, tell a friend or share our website with an animal lover you know!
http://www.save-an-angel.org/main.html or http://www.facebook.com/profile.php?id=100000390876073#!/profile.php?id=100000390876073

 I'll update tomorrow to let everyone know Angel's progress :)

Kristie Sullens -- Angel's Mama
ksullens@save-an-angel.org

Lymphosarcoma in Dogs

Lymphosarcoma in Dogs

Monday, March 22, 2010

Canine Bone Marrow Transplant Success Rates

We receive inquiries on a daily basis regarding the success rates of dogs that have undergone the bone marrow transplant procedure.  That’s why we turned to North Carolina State University’s trusted staff to fill us in on the statistics and this is what they had to say: 


There is no exact percentage yet, but there is a 50%-60% success/cure rate in humans with Lymphoma receiving this same treatment.  It will take at least 2 years to definitively say what the long term success rate is in dogs with B cell lymphoma that are receiving this treatment.


Fact:  95% of transplant procedures used in humans were tested on dogs first.  
As of 3/22/10, NCSU’s BMT Unit has performed the procedure on 14 dogs with B-cell Lymphoma.  Angel will be number 17.


Number of dogs with B cell lymphoma that have received the bone marrow transplant = 14
  • 9 are in remission living cancer free lives!
  • 2 died from causes un-related to lymphoma.
  • 3 have relapsed; 2 are deceased, and 1 is back on chemotherapy and doing well.   Dogs who relapse seem to do so within 4 months post transplant.
The longest survivor post-transplant is 15 months and the second longest is at 13 months! Other recipients are 1 to 10 months out from the date they received the BMT.  Only time will tell the true success and cure rate.


These statistics are incredible!  Especially when you consider this; 98% of dogs that receive chemotherapy alone will relapse within 6 months to 1 year.  


Angel is in complete remission and with your help she'll stay that way :)   Please visit our website for more information on the procedure and to find out how you can help get these dogs to the cures they helped create!  http://www.save-an-angel.org/


For more information about NCSU's Bone Marrow Transplant Unit please click here, http://www.ncsu.edu/featured-stories/innovation-discovery/september-2008/bone-marrow/index.php







Wednesday, March 10, 2010

Diagnosis Cancer - Destination Cure! How it all began...




My name is Kristie Sullens.  My husband Johnny and I live in Metairie, la with 2 dogs that we love like children.  Johnny and I were married in New Orleans on 7/11/2001; just 6 short years after getting together.)  Romeo was the ring bearer and Angel was the flower girl. 2 weeks after tying the knot Johnny found a lump on Angel’s belly;  he made this discovery during their daily Poochie Pilates session.  

We immediately contacted our trusted family vet, Dr. Tosh @ Clearview Animal Hospital www.clearviewvet.com.  Dr. Tosh got Angel in right away and ran some blood work to try and diagnose the lump.  She started Angel on 2 medications; 1. Antibiotics to take the swelling down.  2.  Drug to help with stopping cell regeneration in case it was a mast cell tumor.  The following week we received a call from Dr. Tosh’s office; they said the tests came back negative for cancer, so to stop the 2nd medication.  We were to continue the antibiotics & contact Dr. Tosh if the tumor persists.  2 weeks later the lump had been slightly reduced, but it was still very noticeable.  The most alarming part was Romeo’s constant pestering.  Romeo is very laid back, so when he started fussing over Angel's tummy 24/7 we paid attention. Angel returned to the clinic so that they could get a deep tissue sample of the lump. 4 days later the tests came back and Dr. Tosh called to give us the news; Angel tested positive for cancer and she would need to begin treatment ASAP!                     

Dr. Tosh referred us Dr. Catherine Garon of Riverlands Animal hospital in LaPlace, La.  I composed myself, held back a tidal wave of tears and immediately called Riverlands Animal Hospital www.riverlandsanimalhospital.com ; they set Angel up for "staging" the following week. Angel, Johnny, Romeo & myself went to Angel's appointment as a family.  Dr. Garon began talking to us about “quality of life” and she expressed sincere empathy about our situation.  Dr. Garon explained that 5 year old dogs aren't supposed to die, but  unfortunately when dealing with lymphoma, the past has offered little options.  The doc could give her chemotherapy, but radiation was not an option due to the location of the tumor.  This meant we'd be able to buy Angel 6 months to 1 year of life, 6 months of that is chemotherapy.  It’s not uncommon for dogs to relapse during chemotherapy.  The fortunate dogs make it up to 6 months after the chemotherapy has ended.  Every time a dog relapses, the remission times get shorter.  

Fact: 98% of dogs who receive chemotherapy alone will relapse within 6months to 1 year; only 0-2% survives. These statistics are unthinkable!  Especially since dogs are affected by cancer 3 times more often than humans.  

 Johnny and I were in shock to say the least, and that’s when Johnny asked the doctor about a cure.  With so many advancements in science he just knew that there had to be something out there that could save Angel’s life.  The doc ran a few more tests to “stage” Angel; this is where they tell you if the cancer is stage 1-5, 1 being the best.  When the doc came back she looked frazzled & excited.  She said, “You wanted a cure, you got it!”  While we were waiting for Angel, the doc was calling her colleagues around the country.  They all came to the same conclusion; the only cure for canine lymphoma is a Canine Bone Marrow Transplant.  North Carolina State University began offering this procedure to the public in 2008.  

Our hopes soared when we heard about this wonderful opportunity save Angel!  The doc told us the procedure costs $16,000, then Johnny asked how long we had to raise the money.  The doc said the treatment is available to dogs that are in remission for the first time, so if all goes well she can receive the cure at the end of her 25 week chemotherapy protocol; all did go well and that's why we are here!  Once chemo is stopped there are no guarantees. That’s why we are thrilled that BMT (Bone Marrow Transplant) and chemo are back to back; this leaves zero time for relapse.  

What followed next were a series of tests to qualify Angel for the procedure.  The shaved areas on her body are from treatment; chemo slowed her hair growth so that’s why they are still there.  The shaved area on her chest is from the bone marrow aspirate (needle into bone); this was necessary to determine if she was a B-Cell or a T-Cell patient.  Angel is a B-Cell which is ideal because it responds beautifully to the procedure.  

The shaved areas on her belly are from the ultra sounds & echo they conducted to check her organs; they do a final check on March 18, 2010.  The shaved areas on the front of her legs are from where they administer the chemotherapy.  Each week is a different drug; Angel hasn’t had any bad side effects from treatment itself, only from the prednisone. The protocol she is using is the Madison Wisconsin Protocol-Short which lasts for 25 weeks.  During chemo Angel was on prednisone, omega 3’s and occasionally she was put on Anti-biotic.  We believe that chemo gives her super human strength ;)    

Angel was diagnosed with stage II lymphoma and began chemotherapy on 9/24/09.   When Angel arrived for her 2nd week of chemo her white blood cell count was too low to administer treatment. The doctor assured us that this is what chemo does and we would pick-up week 2 the following week. 

Week 3 we went back & Angel was in complete remission after only 1 treatment!!  This was amazing news and we were very excited to say the least ;)  We would continue treatment until the end of the protocol, but Angel is in remission!   The tests came back and confirmed that Angel is a perfect candidate for the bone marrow transplant, let the fundraising begin!    Now, Angel is nearing the end of her 25 week protocol; it has been extended by 3 weeks.  One of the reasons that chemo isn’t very effective on animals is because the vets won’t make them sick.  After dealing with Angel not being able to take care of herself, I find this commendable.  The doc can’t explain what is happening to them, so the animals won’t want to come back.  Plus, it’s awful to see an animal in a position where they can’t take care of themselves.  Angel couldn’t hold her bladder while she slept after starting the prednisone.  I could tell how bad it made her feel to potty in her bed, and it broke my heart!   Once the 28 weeks are complete, the preparations for the transplant will begin.  The doctor will begin getting her stem cells prepared for the surgery; we were warned that Angel is at risk to become ill.  It doesn’t happen to every dog, but sometimes these medications make them nauseous or dehydrated, causing hospitalization.  

That is how Angel was dignosed and how we were informed about the cure :)  I'll be posting many more updates to this blog, our facebook page http://www.facebook.com/profile.php?id=100000390876073 , & our website http://www.save-an-angel.org/ 

Thank you so much for reading this :)  Please pass us along and help us Save-An-Angel!!